The APO Secretariat organized an online observational study mission on Enhancing the Participation of Persons with Disabilities (PWDs), 24–25 April. It was designed to encourage participants to evaluate the role of policies and advocacy in promoting disability inclusion in the Asia-Pacific, explore innovative models for disability-inclusive social and business practices, and showcase examples of promoting participation by PWDs.  Twenty-six participants and observers from nine APO members completed the course, guided by seven resource persons: three from Japan and one each from Bangladesh, Pakistan, Switzerland, and the UK. Participants gained a comprehensive understanding of the impact of policies and global platforms on disability inclusion in the Asia-Pacific; inclusive and innovative social and business models, human resources management, and skill development enhancing PWDs’ participation as well as their inclusion in disaster management and volunteer activities.